Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis
Abstract ACE2 overexpression in colorectal cancer patients might increase susceptibility to SARS-CoV-2 infection.We report that knockdown, forced overexpression, KIDSROOM and pharmacologic inhibition in human colon cancer cells targeted ACE2-BRD4 crosstalk to mediate marked changes in DNA damage/repair and apoptosis.In colorectal cancer patients fo